Endocrine Abstracts

Objectives: To evaluate the prevalence of subclinical hypertension detected by ambulatory blood pressure monitoring (ABPM) and its relationship with some clinical and epidemiological factors in normotensive and normoalbuminuric patients with type 1 diabetes.Patients and methods: Transversal study that included patients with type 1 diabetes, older than 18 years, with clinic blood pressure lower than 130/80 mmHg and absence of microalbuminuria. Twenty-four...

Introduction: Altered nutritional status is a problem in itself that can complicate a patient’s disease. In our hospital, the assessment of nutritional status at hospital admission is protocolized and performed by the Clinical Laboratory automatically, through the CONUT system, for three years ago. Our hospital provides assistance to a population of 120,000 patients, from rural areas and with a high average age. Hospital admissions for cognitive impairment are increasing ...

Introduction: Aggressive pituitary tumours are rare (<2% of pituitary macroadenomas) and are characterized by local invasiveness, progressive growth, and multiple recurrences despite conventional treatments. Approximately 30-40% of these tumours are functioning corticotroph adenomas. Diagnosis relies on clinical, imaging evaluation with magnetic resonance imaging (MRI), hormonal, and pathological assessments. Its therapeutic approach is challenging.C...

Objective: Analyse possible effects on physical examination, blood count, liver and kidney function, and steroidogenic hormones synthesis. Know the satisfaction of patients with the first injectable treatment for hypercholesterolemia approved in our country.Material and methods: Data were collected from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors. Clinical, physical and analytical data were collected at baseline...

Background: Pituitary adenomas (PA) are common intracranial tumors that are mainly considered benign. A small group of patients exhibit clinically aggressive behavior sometimes unrelated to the histopathological or radiological features.Methods: Twelve patients were selected harboring a PA with clinical features of aggressiveness. All the patients underwent pre and postoperative endocrinologic/neuroradiologic evaluation.Results: 10...

Introduction: Insulinomas are the most frequent cause of endogenous hypoglycaemia. 90 to 95% of these are benign. Surgical enucleation or resection is the standard treatment. Medical therapy focuses mainly on the use of diazoxide with few alternatives in patients with high surgical risk.Case-report: Female patient, 89 years-old, non-diabetic, with previous history of acute myocardial infarction, stroke with motor sequelae, pacemaker carrier and severe ao...

Introduction: The microvascular complications of diabetes and consequent autonomic neuropathy may cause changes in saliva’s secretion and composition. Hyperglycemic levels can also contribute to various oral pathological changes due to alteration of fungi or bacterial flora and dental biofilm surface, leading to the onset of candidiasis, periodontitis and dental caries. The aim of this study was to determine total bacterial load of saliva and dental biofilm of diabetic pa...

Precedents: Thirty-nine year old Woman. Classic phenylketonuria diagnosed for neonatal screening in Germany. Good adherence to the diet from the infancy, with good metabolic control. Not response to test with BH4.Pregnancy in 2007 with good controls of phenylalanine (Phe). Son with congenital cardiopathy.Evolution: In 2013 she planed new pregnancy, departing from very good controls (<4 mg/dl) and ingestion of 22–24 Phe&#14...

Introduction: Parenteral nutrition (PN) is indicated in patients in which gastrointestinal tract is inaccessible or is severely affected. In our hospital, specialists often use commercial three-compartment bags of PN that provide standard nutritional requirements regardless a total parenteral nutrition (TPN) with macro and micronutrients adjusted to each patient by Endocrinology and Nutrition Service.Objectives: To assess the use of commercial premixed P...

Introduction: Pituicytoma is a low-grade glioma of the suprasellar and sellar regions that is rarely described (about 60 cases described in the literature). The clinical, laboratory and neuroradiological findings are not pathognomonic, and therefore definitive diagnosis is only possible after surgery and histopathological study. Total resection is the treatment of choice, since subtotal removal can often lead to recurrence or progression.Case report: We ...